Adaptagen-α is a compound preparation made of extracts from Ostreae testa, Morindae radix and Pachyma hoelen, and alkaloid fraction isolated from Panax ginseng, We evaluated the in vivo effect of adaptagen-α on the production of cytokine and
the
proliferation of spleen cells, and on the changes of blood cell population of mice treated with adriamycin. It has been reported that microbial components such as LPS, BCG and MDP could protect and/or recover from injury by irradiation and their
effects
may be attributed to enhance the release of IL-1. Adaptagen-( was intraperitoneally injected everyday for a week. The treatment enhanced IL-1 production by macrophages as well as IL-4 by spleen cells. One mg of adaptagen-( was a optimum
concentration
for increased IL-1 production by macrophages, whereas IL-4 was increased in spleen cells from mice treated with 100mg of one. When mice were administrated orally with 10mg of adaptagen-(/day for a month, their spleen cells showed higher
proliferative
response to con A or LPS. Although total WBC counts were not significantly influenced by adaptagen-(, percentile proportion of lymphocytes in blood cell population was increased. In conclusion, these data document that adaptagen-( is a
IL-1-inducer
and
its effectiveness for radio- or chemo-protection may be due to enhance the proliferative responsiveness of lymphocytes through increased IL-1 and IL-4 production.
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